abstract：:The liver is key to glucose homeostasis. Any disruption of its metabolism, structural integrity, or intracellular dynamics may alter the liver's ability to maintain normal glucose homeostasis. When such disruption affects hepatic glucose output, hypoglycemia may eventuate. Multiple drugs including alcohol may alter th...

journal_title：Endocrinology and metabolism clinics of North America

authors： Arky RA

更新日期：1989-03-01 00:00:00

abstract：:An approach to the diagnosis and follow-up of patients with osteoporosis is described. A system of classification of vertebral fractures is outlined, and the relative merits of different techniques for bone mineral density are discussed. The importance of identifying factors that accelerate bone loss is stressed. The ...

journal_title：Endocrinology and metabolism clinics of North America

authors： Eastell R,Riggs BL

更新日期：1988-09-01 00:00:00

abstract：:Ambiguity of the external genitalia may be based on disordered steroid biosynthesis or may arise from fundamental genetic and chromosomal abnormalities that produce failure of gonadogenesis. This article first discusses congenital adrenal hyperplasia and then considers the diverse abnormalities that cause disordered g...

journal_title：Endocrinology and metabolism clinics of North America

authors： New MI,Josso N

更新日期：1988-06-01 00:00:00

abstract：:Serum prolactin is reliably elevated by the antipsychotic drugs. Prolactin levels have been followed in psychotic patients during the use of these drugs as an indicator of underlying pathophysiology or as a reflection of drug activity. Considerable research is underway to elucidate further the potential clinical and r...

journal_title：Endocrinology and metabolism clinics of North America

authors： Green AI,Brown WA

更新日期：1988-03-01 00:00:00

abstract：:The dexamethasone suppression test has undergone unprecedented study among the biologic tests proposed for clinical use in psychiatry. Since the 1970s, its study has involved hundreds of reports and thousands of patients. Although important technical aspects of the test appear to be well accepted and validated, additi...

journal_title：Endocrinology and metabolism clinics of North America

authors： Arana GW,Mossman D

更新日期：1988-03-01 00:00:00

abstract：:Osmoreceptor sensitivity is enhanced in healthy elderly subjects and AVP secretion is increased, relative to that of younger subjects, when plasma osmolality rises. Increased AVP secretion/unit increase in plasma tonicity reflects a decrease in collecting tubule sensitivity to AVP by an as yet unknown mechanism in the...

journal_title：Endocrinology and metabolism clinics of North America

authors： Davis PJ,Davis FB

更新日期：1987-12-01 00:00:00

abstract：:Prolactin-secreting pituitary tumors are not rare. The diagnosis of a patient with hyperprolactinemia and possible tumor should be carried out in an orderly fashion by first excluding secondary causes. If the patient has pathologic hyperprolactinemia, assessment of pituitary anatomy with a high resolution CT scan (or ...

journal_title：Endocrinology and metabolism clinics of North America

authors： Vance ML,Thorner MO

更新日期：1987-09-01 00:00:00

abstract：:In this article, new avenues in the understanding of immunologic processes involved in hypothyroidism have been explored. The discovery of a family of TSH-R directed antibodies, including TSI-block, TGI, and TGI-block, has afforded perspectives on the etiology of autoimmune thyroid disorders. Thus, whereas TSI and TSI...

journal_title：Endocrinology and metabolism clinics of North America

authors： Dussault JH,Rousseau F

更新日期：1987-06-01 00:00:00

abstract：:All of the actions of atrial natriuretic factor (ANF) can be explained on the basis of ANF's interaction with specific receptors on the plasma membrane of cells in target tissues. These receptors have been identified. Binding to these receptors by ANF is time dependent and specific and occurs with high affinity. Numer...

journal_title：Endocrinology and metabolism clinics of North America

authors： Jacobs JW,Vlasuk GP,Rosenblatt M

更新日期：1987-03-01 00:00:00

abstract：:Since its discovery, ANF has provided multitudinous opportunities to explore its relationship to various biologic functions. Hundreds of publications investigating various aspects of this newly discovered hormone system have appeared. ANF exhibits a plethora of direct and indirect biologic activities that oppose the h...

journal_title：Endocrinology and metabolism clinics of North America

authors： Adams SP

更新日期：1987-03-01 00:00:00